BIOC34H3 Lecture Notes - Lecture 6: Stroke Volume, Diastole, Muscle Contraction
Document Summary
End diastolic volume is the ventricular volume at the end of diastole - when ventricular volume is at its greatest level. Pre-load = degree of ventricle stretching at the end of diastole. Think of it as the end diastolic pressure (edp) in the ventricles. If you increase the pressure of blood in the atria and then the ventricles, the volume of blood in the ventricle (edv) is going to increase. This initial pressure (within the ventricles; prior to contraction) is referred to as preload. The ventricular pressure-volume loop shows the effects of reducing pre-load (end-diastolic pressure) on end-diastolic volume (edv) and therefore on sv. Following isovolumetric relaxation (d), volume of blood in the ventricle is the end-systolic volume (esv). Then the ventricular filling phase and the volume of the ventricle increases to edv1 at an end- diastolic pressure of edp1 sv1 = edv1 - esv. If end-diastolic pressure is reduced to edp2, then end-diastolic volume is reduced to edv2.