BIOC34H3 Lecture : Lecture 23 Notes.pdf

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20 Apr 2014
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Lecture 23: liver function; digestion and absorption of carbohydrates, proteins and. Another function of the liver is the recycling of old red blood cells and the components of haemoglobin. Red blood cells have a lifespan of approximately 45-50 days before they are recycled by being taken-up into macrophages. Within the macrophage, haemoglobin is broken down into globin molecules (which are further broken down into amino acids and released into the blood) and the heme group. The heme group is then converted into biliverdin and then reduced to bilirubin. Bilirubin is released from the macrophage and binds with plasma albumin in the blood which transports it to the liver. Within the liver bilirubin is conjugated with glucuronic acid to form a component of the bile which is then released into the small intestine. Within the small intestine, bilirubin is metabolized by gut bacteria to produce urobilinogen.

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