BIOC39H3 Lecture Notes - Lecture 10: Complement Receptor 2, Syk, Cd19
8 Apr 2015
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Their role is simply to bind tightly to pathogens. Neutralize: covering up the sites on the pathogen"s surface that are necessary for growth and reproduction. Opsonization: act as molecular adaptors that bind to pathogens with their antigen-binding-arms and to receptors on phagocytic cells with their fc regions, promoting phagocytosis. Induces the classical pathway of complement activation, further enhancing phagocytosis. B cells become activated when their receptors are cross-linked by antigens. The cluster of receptors activates cytoplasmic protein tyrosine kinases. Many cell surface proteins have cytoplasmic kinase domains. Kinase domains phosphorylate substrates (other proteins: tyrosine (tyrosine kinases, serine/threonine (serine/ threonine kinases) Receptor tyrosine kinases (rtks) are often dimerized by ligand: leads to rtk trans-phosphorylation and activation. Bcr = sig + ig / ig . Cytoplasmic tails of ig and ig each contain 2 itams: associates with tyrosine kinases blk, gyn, lyn.
