BIOC39H3 Lecture Notes - Lecture 21: Myelin Basic Protein, Diabetes Mellitus Type 1, Autoimmune Disease
8 Apr 2015
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Document Summary
Self-tolerance: the guard against attack one"s own cells and tissues in the populations of circulating b and t cells. Immunologically privilege sites: sites that are not accessible to circulating leukocytes, brain, eyes, testis, uterus (during pregnancy) Autoimmune diseases: diseases caused by adaptive immunity that becomes misdirected at healthy cells and tissues of the body, failure of self-tolerance, vary in the tissues they attack and symptoms, affect 5% of the population in developed countries. Immune response directed toward autologous (self) components of the body: caused by autoantibodies (antibodies) and autoimmune t cells (inflammatory t cells) directed against autoantigens (self-antigens) Three kinds of autoimmune disease correspond to the type ii, ii, and iv hypersensitivities: no autoimmune diseases are caused by ige (no type i) Type ii autoimmune disease: caused by antibodies directed against components of cell surfaces or the extrtacellular matrix. Type iii autoimmune disease: caused by soluble immune complexes deposited in tissues. Type iv autoimmune disease: caused by effector t cells.
