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Lecture 13

BGYB51H3 Lecture 13 Notes Oct 22


Department
Biological Sciences
Course Code
BIOC51H3
Professor
Maydianne Andrade
Lecture
13

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BGYB51H3 Lecture 13 Notes
-HIV is a retrovirus that carries reverse transcriptase to convert RNA to DNA and carries
integrase to integrate DNA and protease
-GP120 is the surface protein that binds to the membrane
-CD4 protein and co-receptor bind with GP120 protein of HIV
-in reverse transcription of HIV, DNA is created from RNA
-HIV evolution involves selection inside the body of the host and selection across the
population of the host
-HIV infects helper T cells that recognize foreign proteins, activate killer T cells and signals
antibody production
-AZT is a treatment of HIV in which it ends reverse transcription
-HIV evolves resistance to AZT because of mutant forms of HIV reverse transcriptase arising
-mutations can cause resistance of HIV in which viral strains present late are different from
strains present earlier
-an epitope is a piece of protein displayed on host cells or virions
-epitopes become differentiated through mutation
-a drug is an agent of selection in which variants of the viral strain can be resistant to the drug
and replicate more than other variants
-HAART treatment is used more often by using multi-antiviral drugs at once
-HIV is fatal because there is natural selection within the host, viral transmission between hosts
and inability to resist
-virulence is the tendency to cause a disease in a host
-P32 mutations make HIV unable to enter the cell
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