BGYB51H3 Lecture 13 Notes Oct 22

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Published on 11 Aug 2010
School
UTSC
Department
Biological Sciences
Course
BIOC51H3
BGYB51H3 Lecture 13 Notes
-HIV is a retrovirus that carries reverse transcriptase to convert RNA to DNA and carries
integrase to integrate DNA and protease
-GP120 is the surface protein that binds to the membrane
-CD4 protein and co-receptor bind with GP120 protein of HIV
-in reverse transcription of HIV, DNA is created from RNA
-HIV evolution involves selection inside the body of the host and selection across the
population of the host
-HIV infects helper T cells that recognize foreign proteins, activate killer T cells and signals
antibody production
-AZT is a treatment of HIV in which it ends reverse transcription
-HIV evolves resistance to AZT because of mutant forms of HIV reverse transcriptase arising
-mutations can cause resistance of HIV in which viral strains present late are different from
strains present earlier
-an epitope is a piece of protein displayed on host cells or virions
-epitopes become differentiated through mutation
-a drug is an agent of selection in which variants of the viral strain can be resistant to the drug
and replicate more than other variants
-HAART treatment is used more often by using multi-antiviral drugs at once
-HIV is fatal because there is natural selection within the host, viral transmission between hosts
and inability to resist
-virulence is the tendency to cause a disease in a host
-P32 mutations make HIV unable to enter the cell
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Document Summary

Hiv is a retrovirus that carries reverse transcriptase to convert rna to dna and carries integrase to integrate dna and protease. Gp120 is the surface protein that binds to the membrane. Cd4 protein and co-receptor bind with gp120 protein of hiv. In reverse transcription of hiv, dna is created from rna. Hiv evolution involves selection inside the body of the host and selection across the population of the host. Hiv infects helper t cells that recognize foreign proteins, activate killer t cells and signals antibody production. Azt is a treatment of hiv in which it ends reverse transcription. Hiv evolves resistance to azt because of mutant forms of hiv reverse transcriptase arising. Mutations can cause resistance of hiv in which viral strains present late are different from strains present earlier. An epitope is a piece of protein displayed on host cells or virions.