BIOC12H3 Lecture Notes - Lecture 5: Amniote, 310 Helix, Phenylalanine
23 Sep 2016
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And thus can study interaction between atoms in close proximity d. ii. Combine information with the amino acid sequence d. iii. Useful for small proteins, but not large proteins. Bovine ribonuclease a: nmr structure, shows protein backbone a. i. Disulfide bridges in yellow are not seen in crystal structure: similar to ribbon diagram structures of ribonucleases from cow and human c. Structure of the peptide bond: peptide group, defined as two atoms involved in peptide bond a. i. Two adjacent alpha carbons: has a rigid planar structure b. i. Consequence of resonance interactions that give the peptide bond a 40% double bond character. Resonance structure of the peptide bond: two double bond forms (resonance structures, electrons are delocalized around carbonyl (c=o, electrons are delocalized around nitrogen (c=n) b. i. Rotation around the c-n bond is restricted due to the double bond nature of the hybrid: result of hybrid structure is that the atoms of the peptide bond lie in the same plane.
