BIOC33H3 Lecture Notes - Micelle, Micro Instrumentation And Telemetry Systems, Rhodopsin
4 Oct 2014
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Liver function removal of old rbcs: iron from haemoglobin is recycled, macrophages engulf rbcs, stercobilin gives the brown colour to faeces, urobilin gives the amber colour to urine. Jaundice = excess bilirubin in the skin: liver malfunction due to hepatitis or alcohol damage, blockage of bile duct; gallstones or tumours, excess rbc breakdown; malaria; newborn babies. Iron deficiency = absorption increases; transport increases; very rapid transport out of the cell; reduction in intracellular iron. Excess iron = transferrin becomes saturated; apoferritin and ferritin increased; iron is sequestered on ferritin; lost when cells shed. Diferric transferring receptor complex is taken within an endosome. Low endosome ph releases the fe2+ from transferring. Iron is pumped into cytosol by divalent metal transporter (dmt1) Apotransferrin (apo-tf) is removed from cell by exocytosis. Hydrophobic to hydrophilic (to allow for excretion by the kidney) Alcohol damages to the liver ==> interferes with mitochondrial function in hepatocytes leading to lipid accumulation.
