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Lecture 6

Lecture 6


Department
Biological Sciences
Course Code
BIOD27H3
Professor
Ingrid L.Stefanovic
Lecture
6

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Lecture 6
Chemical Synapse (2)
30th Sep
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Lecture Outline
Types of neurotransmitters
Biosynthesis, release and catabolism of
neurotransmitters
Neurotransmitter receptor subtypes
Second messenger cascades
Physiological role of neurotransmitters and receptor
subtypes
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Neurotransmitters: Can be classified based by chemical
composition: Amines, Amino Acids, Acetylcholine
Amines:
±synthesisedin body
-derived from amino acids
Derived from tyrosine
(CATECHOLAMINES)
__dopamine (DA), norepinephrine/
noradrenaline (NA),
epinephrine/adrenaline (Ad)_______
Derived from tryptohan
__serotonin (5-hydroxy-tryptanine 5-HT)___
Amino acids:
-taken in through diet
From glutamine
-_glutamate (excitatory)____
From glutamate
-__GABA (inhibitory) _Gama
amino butyric acid________
__________________
Acetylcholine:
±synthesised in body
-derived from _choline_ and
_acetyl-coA_____________
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