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BIOB34H3 Lecture Notes - Basal Metabolic Rate, Homeothermy, Thermoregulation

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beigehamster733
10 Jun 2014
School
UTSC
Department
Biological Sciences
Course
BIOB34H3
Professor
Jason Brown

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Document Summary

Slide 2: endotherms generate large amounts of heat via metabolism and use that heat to regulate their body temperature, homeothermy and endothermy occurs largely in mammals and birds. Some bees and fish and reptiles also can be described as endotherms. Slide 3: mammals and birds are unique in that the metabolic heat they use to regulate their body temperature is derived from tissues other than skeletal muscles. Insects, certain fish, and certain reptiles only generate heat via skeletal muscles and can only be endothermic when they"re active and not homeothermic. Slide 4: because of their shared traits of producing metabolic heat and regulate body temperature, mammals and birds were put together in one order of homeothermia. Now we know they came from separate lineages. Their last common ancestor diverged 324 million years ago leaving us with a reptile lineage and mammal lineage.

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Related Questions

1. Diseases are those abnormal conditionsin which the bodys defensive cells fail to make the self versus thenonself distinction correctly, and attack the body's owntissues.
A. Cancerous
B. Septic
C. Autoimmune
D. Nondiscrete

2. Which of the following determinesgenetic sex (male or female) in mammals?
A. the acrosome of the sperm
B. the temperature of the developing fetus
C. the SRY gene on the Y chromosome
D. the genetic makeup of the parents
E. the Y chromosome contained in the egg

3. Which of the following regardingantigens is true?
A. Antigens can only be recognized by their specificity.
B. An antigen is a molecule which promotes a general immuneresponse.
C. A large antigen is likely to have many different epitopes, eachof which can stimulate a distinct immune response.
D. The most effective antigen are small simple amino acidcomplexes.
E. Bacteria do not contain antigens.

4. All of the following are defensemechanism employed by vertebrates except

A. negative test, as in, not findingself-markers.

B. change in chromosomal composition

C. positive test to recognize presence ofnonself-markers

D. specific antibodies.

E. skin and mucous membranes asbarriers.

5. The immune system depends on thefunction of ______, which include several types of phagocytic cellsand two kinds of lymphocytes.

A. platelets

B. leukocytes

C. target cells

D. erythrocytes

6. In comparing the kidneys of marine andfreshwater fish, which of the following is not true?

A. Freshwater fish fluids have a greaterosmotic concentration.

B. Marine fish excrete many of the divalentcations through the anus.

C. The flow of the filtrate is faster inmarine fish.

D. The urine is less concentrated infreshwater fish.

E. Marine fish drink greater quantities ofwater.

7. The kidneys of which one of thefollowing are so highly efficient that it never has to drink waterand can obtain all of its water from its food?

A. desert lizard

B. camel

C. pocket moue Perognathus

D. kangaroo rat

E. gerbil

8. Select the incorrect statement regardingthe temperature of the immune system.

A. Interleukin-1 is a pyrogen, which cancause the neurons in the hypothalamus to raise the body'stemperature, producing a fever.

B. Fevers cause the liver and spleen tostore sodium and potassium which bacteria need for their growth andmetabolism.

C. Fevers above 105 ° F can be fatal.

D. Fever contributes to the body's defensesby stimulating phagocytosis.

E. When macrophages encounter invadingcells, they release interleukin-1, which is carried to the brain bythe circulatory system.

9. Which of the following is not amechanism to prevent polyspermy?

A. change in membrane otential of egg

B. vitelline envelopes lift off surface ofegg

C. sperm nuclei degraded inside eggallowing one to fuse

D. cortical granule enzymes remove spermreceptors from egg

E. altering composition of exterior eggcoat

10. Which of the following cells have anincorrect function?

A. neutrophil---important antigenpresenting cell

B. eosinophil---important to theelimination of parasites

C. mast cell---releases histamine

D. macrophage---phagocytic cell

E. monocyte---precursor of macrophage

11. Which part of the antibody moleculedetermines its role in the immune response?

A. disulfide chains

B. the entire molecule

C. the stem of the Y

D. the heavy chains

E. two arms of the Y

12. Select the incorrectly matchedimmunoglobin (Ig)subclass and a fact about it.

A. IgG---found in the plasma and secretedin secondary response

B. IgM---first secreted during primaryresponse

C. IgE----promotes the release ofhistamine

D. IgA----found in saliva and mother’smilk

E. IgD----serve as receptors on thesurfaces of T cells

13. _______ are the source ofantibody-producing cells.

A. B cells

B. Plasma cells

C. Monocytes

D. Macrophages

E. T cells

14. Select the incorrect statementregarding the inflammatory response.

A. The alarm signals can be histamines orprostaglandins.

B. The inflammation response is a localizedspecific response to infection or injury.

C. Neutrophils spill chemical in the areaof injury or infection that kills bacteria, tissues, andthemselves.

D. Tissue can exhibit edema from thedilation of the blood vessels in the area of injury orinfection.

E. If a cell is injured or infected, itreleases chemical alarm signals that promote dilation of bloodvessels at the injury site.

15. Reproduction in reptiles compares toreproduction in birds in that

A. both newly hatched birds and reptilesrequire parental care.

B. the eggs of both birds and reptiles haveprotective shells.

C. birds are oviparous, reptiles areovoviviparous.

D. both exhibit external fertilization.

E. male or female reptiles reproduceasexually; birds do not.

16. ______diseases are those abnormalconditions in which the body’s defensive cells fail to make theself versus the nonself distinction correctly, and attack thebody’s own tissues.

A. Cancerous

B. Septic

C. Autoimmune

D. Nondiscrete

17. Most marine invertebrates areosmoconformers. This means that

A. the osmolality of their body fluids isequal to that of the osmoregulators who inhabit the sameenvironments.

B. the osmolality of their body fluidsfluctuates between being hypertonic to hyportonic depending on theseason and the tides.

C. the osmolality of their body fluids isnot the same as their seawater environment

D. the osmolality of their body fluids isthe same as their seawater environment and that their bodiescontain the same solutes as their surroundings

E. the osmolality of their body fluids isthe same as their seawater environment

18. Which of the following determinesgenetic (male or female) in mammals?

A. the acrosome of the sperm

B. the temperature of the developingfetus

C. the SRY gene on the Y chromosome

D. the genetic makeup of the parents

E. the Y chromosome contained in theegg





If you can please explain why and how yougot the answer. 5 star rating for correct answers only, I have theanswer sheet, and just want to double check.

10. The organs associated with the Alimentary Canal share which similarity/similarities? They all belong to the lymphatic system They all belong to the gastrointestinal system Food does not pass directly through them during the process of digestion Food does pass directly through them during the process of digestion Both B and D \

11. Of the five basic functions of the digestive system, which one occurs first? Excretion Absorption Ingestion Peristalsis Digestion

12. The elimination of indigestible material from the body is called _______________. Peristalsis Absorption Defecation Ingestion

13. The pancreas helps to regulate metabolism and blood sugar levels through the release of insulin. Insulin tells the liver to stop sugar production to keep levels regulated within the blood stream. If a person’s pancreas does not function properly, they have a condition called diabetes, a metabolic disease that often requires monitoring of one’s diet. People with Type 1 Diabetes have a pancreas with damaged islet cells, meaning no insulin is produced. People with Type 2 Diabetes have a pancreas that produces insulin properly, but their cells are resistant to this insulin due to various factors that often include but are not limited to obesity, lack of exercise, or poor diet choices. Certain foods, specifically starches and sugars, affect diabetics in different ways. Type 1 diabetics must limit their consumption of sugars in order to keep their blood sugar levels stable. Type 1 diabetics often achieve regulation of blood sugars through injections of insulin. Type 2 diabetics must still pay attention to their diets, but not all of them are dependent on manual injections of insulin. Because Type 2 Diabetes is often brought on through a poor diet, Type 2 diabetics are advised to monitor their food choices to prevent weight gain and achieve a more balanced diet overall. Approximately 90% of Americans with diabetes have Type 2. Which are contributing factors to developing Type 1 Diabetes? Poor liver function Poor pancreatic function Sedentary lifestyle All of the above

14. There are five activities that occur within the gastrointestinal system: • Ingestion – the taking in of food or drink • Peristalsis – the movement of food along the digestive tract • Digestion – the breakdown of food and drink by both mechanical and chemical mechanisms • Absorption – the passage of food into the cardiovascular and lymphatic systems • Defecation – the elimination of substances the body can’t use Many digestive disorders and diseases can be tied to an activity within the gastrointestinal system. For example, inflammation of the digestive tract, commonly known as inflammatory bowel disease, is an example of a gastrointestinal activity breakdown. An inflamed digestive tract means digestion is painful and hindered in some way, affecting the rest of the gastrointestinal activities coming after it. An inability to break down lactose, or “lactose intolerance,” is another example of a breakdown that can occur within the gastrointestinal system. Another example of a breakdown in gastrointestinal activities is an eating disorder, where food is either withheld or ingested at a fast rate. Some disorders include the elimination of food through vomit, in essence reversing some of the activities of the gastrointestinal system. A final example of a breakdown in gastrointestinal activities is constipation, which can often lead to further problems such as bowel impaction if not corrected immediately. A balanced diet is recommended to keep the gastrointestinal system functioning properly, and many over the counter medications can help to correct some breakdowns if caught early enough. Foodborne illness, or food poisoning, happens when spoiled or contaminated food is consumed. A common symptom of food poisoning is vomiting. Though microbes can move from the stomach and into the intestines after vomiting occurs, the food itself gets thrown up, stopping its travel through the gastrointestinal system. During which activity is the food thrown up? Peristalsis Absorption Ingestion Digestion

15. The skin is a vital organ that covers the entire outside of the body, forming a protective barrier against pathogens and injuries from the environment. The skin is the body's largest organ; covering the entire outside of the body, it is about 2 mm thick and weighs approximately six pounds. It shields the body against heat, light, injury, and infection. The skin also helps regulate body temperature, gathers sensory information from the environment, stores water, fat, and vitamin D, and plays a role in the immune system protecting us from disease. The color, thickness and texture of skin vary over the body. There are two general types of skin; thin and hairy, which is more prevalent on the body, and thick and hairless, which is found on parts of the body that are used heavily and endure a large amount of friction, like the palms of the hands or the soles of the feet. Basically, the skin is comprised of two layers that cover a third fatty layer. These three layers differ in function, thickness, and strength. The outer layer is called the epidermis; it is a tough protective layer that contains the melanin-producing melanocytes. The second layer (located under the epidermis) is called the dermis; it contains nerve endings, sweat glands, oil glands, and hair follicles. Under these two skin layers is a fatty layer of subcutaneous tissue, known as the subcutis or hypodermis. The skin contains many specialized cells and structures: • Basket Cells: Basket cells surround the base of hair follicles and can sense pressure. They are evaluated when assessing overall nerve health and condition. • Blood Vessels: Blood vessels carry nutrients and oxygen-rich blood to the cells that make up the layers of skin and carry away waste products. • Hair Erector Muscle (Arrector Pili Muscle): The arrector pili muscle is a tiny muscle connected to each hair follicle and the skin. When it contracts it causes the hair to stand erect, and a "goosebump" forms on the skin. • Hair Follicle: The hair follicle is a tube-shaped sheath that surrounds the part of the hair that is under the skin and nourishes the hair. It is located in the epidermis and the dermis. • Hair Shaft: The hair shaft is the part of the hair that is above the skin. • Langerhans Cells: These cells attach themselves to antigens that invade damaged skin and alert the immune system to their presence. • Melanocyte: A melanocyte is a cell that produces melanin, and is located in the basal layer of the epidermis. • Merkel Cells: Merkel cells are tactile cells of neuroectodermal origin located in the basal layer of the epidermis. • Pacinian Corpuscle: A pacinian corpuscle is a nerve receptor located in the subcutaneous fatty tissue that responds to pressure and vibration. • Sebaceous Gland: Sebaceous glands are small, sack-shaped glands which release an oily substance onto the hair follicle that coats and protects the hair shaft from becoming brittle. These glands are located in the dermis. • Sensory Nerves: The epidermis is innervated with sensory nerves. These nerves sense and transmit heat, pain, and other noxious sensations. When they are not functioning properly sensations such as numbness, pins-and-needles, pain, tingling, or burning may be felt. When evaluating a skin biopsy, total number, contiguity, diameter, branching, swelling, and overall health of the sensory nerves are assessed. • Stratum Corneum: The stratum corneum is outermost layer of the epidermis, and is comprised of dead skin cells. It protects the living cells beneath it by providing a tough barrier between the environment and the lower layers of the skin. The stratum corneum is useful for diagnosis because in some conditions it will become thinner than normal. • Sweat Gland (Sudoriferous Gland): These glands are located in the epidermis and produce moisture (sweat) that is secreted through tiny ducts onto the surface of the skin (stratum corneum). When sweat evaporates, skin temperature is lowered. If you use a product to moisturize your hair, which part of the integumentary system are you targeting? Hair follicle Hair shaft Blood vessels Melanocyte

The people of Malaysia belong to three communities: the local people called Malays, immigrants from South India called Tamils, and immigrants from China. During the early 20th century, the Malays lived mainly in coastal villages, the Tamils worked on rubber estates, and the Chinese worked in tin mines. In general, the people were very poor and they consumed a limited variety of foods.[1] Rice was the staple diet of all three communities and therefore the key source of caloric and nutrient content. Malays typically grew their own rice and dehulled it before consuming it; dehulling partially removes the aleurone layer of the rice seed. Following their South Indian food habits, the Tamils ate parboiled rice, and the Chinese ate polished white rice imported from Thailand. It was found that among the three Malaysian communities, the Chinese community was much more prone to suffer from some degree of sub-optimal thiamin intake. Out of every 1,000 Chinese inhabitants, about 120 had mild thiamin deficiency, about 80 had severe thiamin deficiency, and about 16 people had died of it. Suboptimal intake of thiamin was rare in Malays and was not reported at all in Tamils.[1] Thiamin, also called Vitamin B1, is required for all tissues, and its deficiency causes the disease Beriberi. Less severe deficiency results in non-specific symptoms such as weight loss, malaise, irritability, and confusion. Although the origin of the word Beri-beri is disputed, it is believed to be a Philippine word meaning “I can’t, I can’t” and was probably coined to refer to the lack of neuromotor coordination in people afflicted with this disease.[2] Thiamin is water-soluble and is stable in the acidic medium. It is unstable to heat, oxygen, and UV light in neutral and alkaline medium. The active form of thiamin is thiamin pyrophosphate (TPP). This active form is a cofactor for pyruvate dehydrogenase and transketolase enzymes that are involved in the metabolism of carbohydrates. These enzymes play an important role in the biosynthesis of a number of cell constituents such as neurotransmitters, pentoses, and reduced equivalents, used in oxidant stress. The human body cannot store thiamin and therefore requires a continuous supply of the vitamin. The thiamin in an individual on a thiamin-free diet typically depletes in fewer than two weeks. Thiamin absorption is affected by compounds, called thiamin antagonists or anti-thiamin factors, that alter the structure of thiamin. These compounds include alcohols, polyphenols, flavonoids, and thiaminase, a heat labile enzyme found in certain foods.[2] In affluent countries, where the diet is rich in thiamin, the most common cause of thiamin deficiency is excessive alcohol consumption. Alcohol intake affects thiamin status in two ways. First, alcoholics get a significant percentage of their daily energy intake from alcoholic beverages, which are nutrient deficient. In other words, alcoholics replace their consumption of nutrient dense foods that are part of their normal diet with the consumption of nutrient deficient alcohol. Second, alcohol inhibits the intestinal ATPase involved in the absorption of thiamin.[4] Sub-clinical thiamin insufficiency associated with excessive alcohol consumption produces an encephalopathy called Wernicke-Korsafoff syndrome. Patients with this syndrome have a higher than normal incidence of abnormal transketolase, which has a very low binding affinity to TPP. This problem can be overcome by putting patients on high-dose thiamin therapy. Some patients, however, might have a form of abnormal transketolase that does not bind at all with TPP. Such people do not respond to high-dose thiamin therapy.[4] Thiamin deficiency is observed in individuals who have low thiamin intake and a diet rich in polished rice, especially if their diet also consists of anti-thiamin factors such as tea, coffee, raw fermented fish, and betel nuts. The minimum amount of thiamin needed by the body can increase because of increased physiological or metabolic demands arising from pregnancy and lactation, heavy physical exertion, illnesses like cancer, liver diseases, hyperthyroidism, and surgery. Since TPP is required for carbohydrate metabolism, the recommended dietary allowances for thiamin are based on the assumption that its intake is related to total energy intake. The recommended dietary allowance in the United States is 0.5 mg/1000 Kcal.

Questions
1. Thiamin deficiency was observed only in the Chinese community even though all three
communities had the same staple (rice) diet. Explain.
2. On packages of enriched rice sold in supermarkets, the rice preparation directions state that the
rice should not be washed before cooking. Explain.
3. Severe metabolic acidosis caused by high levels of lactate is often associated with thiamin
deficiency. Explain.
4. Provide two plausible explanations for what might cause above normal levels of pyruvate in blood
and urine. How can one determine which of the two explanations is correct?
5. Why does thiamin utilization increase among cancer patients?
6. A negative correlation exists between the need for thiamin and the amount of fat in the diet.
Explain.