BIOC13H3 Lecture Notes - Lecture 6: Thioester, Gluconeogenesis, Adenylate Kinase
Document Summary
Hexokinase reaction is straightforward, you"re taking a phosphate from atp and put it on glucose, so you get glucose 6 phosphate. Hexokinase has a much broader role in the cell which is that it commits the cell to glucose uptake. Glut transporters that will allow glucose to diffuse in and out of the cell, based on the concentration gradient. As glucose comes in, hexokinase phosphorylates it and prevents the glucose 6 phosphate from exiting the cell because phosphorylated molecules can"t enter/exit cells. Hexokinase job is just to get glucose trapped in the cell. Hexokinase is regulated through a negative feedback regulation. Glucose 6 phosphate (g6p) is an inhibitor of hexokinase. If the cell has a lot of g6p it won"t need to make more of it. 15-16 glut transporters, but only about 4 that we know the role of. Glut1 is ubiquitous, which means that you will find in pretty much every tissue.
