BIOC13H3 Lecture Notes - Lecture 21: Atp Synthase, Electrochemical Gradient, Oligomycin
Document Summary
Atpase usually means you are breaking atp down, so the atp synthase can take atp, hydrolyze it and use it to pump protons and create a gradient. Atp synthase structure is peculiar or unusual. We have the fo domain, embedded in the inner mitochondrial membrane. Also have the f1 domain sticking out in the matrix. Each of these domains has many different proteins. F1 is made up of 3 alpha subunits, 3 beta subunits, 1 gamma subunit, 1 delta and 1 epsilon. Fo is also made up of multiple subunits, a, b, f6 etc and c subunits. There can be different c subunits in different organisms (from 8-15) Delta and epsilon are there to link f1 and fo domain. Function of fo part is to translocate protons, allows protons to flow across the membrane and there is free energy released and use that to synthesize atp. The atp synthesis is done by f1 domain (catalytic domain)