BIOC14 : Lec 11 : Article 3 - Behavioral phenotyping strategies for mutant mice

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Biological Sciences
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Patrick Mc Gowan

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BIOC14 Lec 11Article 3 Discussion Behavioral phenotyping strategies for mutant micey Using behavioral assays to answer questions like whether genes are involved in particular behavioral traits maybe ask whether these are behavioral traits have some predictive value for mental disorders in humans y Important to understand that were not trying to say that a mouse is depressedwe can never say that a mouse is depressedschizophrenic etc o We can say that mouse models schizophreniadepressionpresents certain behavioral phenotypes that are reminiscent of the symptoms of these disorders OR that are responsive to drugs that are effective in humans for treating the symptoms for these diseases y When we talk about phenotypic analysis of human behaviors theres a list of different ways of studying behaviors in animals learningmemory social beh index of general health etcwidely usedhave ability to discriminate among diff strains of mice may be better or worse depending on strain differences or depending on gene thats knocked out may be responsive to some of these assays or may not be y All behavioral assays discussed here use reinforcement or escape LEARNING AND MEMORY spatial navigationy Morris Water Mazeo Pool of water opaque white paint difference in contrast btn animal if blackpool o Navigate in water depending on cues in room o Test of spatial navigation o Platform under water animal may escape o Animal learns where the platform is after repeated trials how quickly animal goes where it goes etc y Barnes Maze o Round area w holes in it one of the holes has an escape hatch animal must find it o Use cues in room o If flip maze 90 degrees will disrupt animals ability to find its wayindication that animal is using cues y Radial Maze o Arms coming out from centre one of the arms has food o Highly motivated and use spatial cues to find the food
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