BGYB30H3 Lecture 18 Notes Endocrinology 1-Nov 10

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Biological Sciences
Ingrid L.Stefanovic

BGYB30H3 Lecture 18 Notes -smooth muscle is found in the walls of hollow organs and tubes in blood vessels -contraction changes shape of organs and moves materials in, out, or around the body -smooth muscle has low fatigue, low oxygen consumption, less energy required to generate force -smooth muscles are small and have a single nucleus in spindle fibres -neurotransmitters and sex hormones control smooth muscles -smooth muscles integrate signals and act based on the majority of neurotransmitters -smooth muscles may hyperpolarize or depolarize depending on the signal -smooth muscles may depolarize without a graded or action potential or a change in membrane potential -in a single unit cell smooth muscle, cells contract as a unit through being connected by gap junctions, which conducts electrical synapses -multi-unit smooth muscle involves cells associated with variscosities with no gap junctions, allowing fine control of contractions -smooth muscle in the uterus goes from multi-unit to single unit during pregnancy -smooth muscle has longer actin and myosin filament -rate of cross bridge cycling is slower in smooth muscle to allow longer contractions -there is less sarcoplasmic reticulum than skele
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