EESA10H3 Lecture Notes - Lecture 5: Immunosuppression, Chisso, Organic Form
8 Feb 2018
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Heavy metals: naturally occurring, extracted from the earth, in ore, wide environmental dispersion, tendency to accumulate in select tissues, toxic in even low concentrations. Cr, cu, as, co, ni, zn, mn, fe. Mechanism of toxicity: blocking essential functional groups such as proteins or enzymes, proteins can not carry anything, displace other metals (class b, borderline, modifying the active conformation of biomolecules (class b) Coping mechanisms: resistance species develop mechanisms not to uptake metal (example pb, tolerance the capacity of a species to withstand high level of metals. Binding to non sensitive compound structures: metabolic transformations to less toxic forms (methylation of as in marine biota) Can develop multiple tolerance - cu, pb, zn, cd. Lec 5 feb 7: species of the metal - free ions (charged ions zn+2 are more bioavailable than zno , neutral species may be bioavailable, important in complexes, ph of solution, redox potential of solution.
