EESA10H3 Lecture Notes - Lecture 9: Absorbed Dose, Toxicokinetics, Vacuum Cleaner
30 Mar 2018
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Document Summary
Introduction to fate and transport: transport: movements of contaminants within or between environmental media, fate: physical, chemical or biological transformations of contaminants in the environment. Exposure: contact with human envelope, routes of exposure: Ingested (often greatest source of chemical exposure, 85%) In conclusion, even though absorbed through the skin is only 5% it is still very dangerous. Opposite direction, more vitamin d, less chances of getting cancer: synergistic: more you smoke, increased chance of getting lung cancer. Disposition of chemicals in the body: toxicokinetics: the disposition of toxicants in the body, body burden, absorption, distribution, metabolism, storage, excretion, toxicodynamics: effects in the body (response) Paracelsus" pri(cid:374)ciple: (cid:862)the dose (cid:373)akes the poiso(cid:374)(cid:863): every chemical is harmful at some level of exposure, how much exposure causes a harmful response, differently for different individuals, the dose of a usually unknown mixture of chemicals. Dose-response curves: two key characteristics, slope (potency of effect, threshold (potential for safe dose, a more realistic flattened s-shape:
