HLTB22H3 Lecture Notes - Lecture 1: Epigenome, Transgenerational Epigenetic Inheritance, Acetyl Group
Document Summary
Mutations can be made on transcription or translation phase. Epigenetic landscape of development: huge implication for initial process of development. Usually because everything that happens epigenetically happens during the developmental process: cells will respond to their environment plasticity. Recall: activation of gene transcription: very mechanical in nature. I(cid:374)flue(cid:374)(cid:272)es o(cid:374) ge(cid:374)e e(cid:454)pressio(cid:374) that are(cid:374)"t dire(cid:272)tl(cid:455) (cid:272)ha(cid:374)gi(cid:374)g the ge(cid:374)eti(cid:272) (cid:272)ode. Other influences that are modifying the transcription/translation process. Dna methylation: specific nucleotides that are going to be affected cytosine. Cytosine can either be methylated or unmethylated. Methylated status determines whether a gene is transcribed or not: unmethylated cytosines tend to show an activation of the gene, methylation on the cytosines can actually save it from mutation. *do(cid:374)"t (cid:374)eed to k(cid:374)o(cid:449): we"(cid:448)e prefere(cid:374)tiall(cid:455) kept (cid:272)(cid:455)tosi(cid:374)es i(cid:374) the pro(cid:373)oter regio(cid:374) Cpg methylation: we tend to look for cpg sites they have cytosines and guanines side by side, dna methyltransferase packs methyl groups onto cytosines resulting in a sop to gene transcription.
