PSYC23H3 Lecture Notes - Lecture 4: Classical Conditioning, Cortisol

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31 Jan 2013
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Hunger and Memory
Protein - brain will work synapses
How body make decisions under this complex conditions
Mild hunger a little bit long study hours might be condusive
Pavlovian Conditioning
Early mechanisms of learning biology figure out best stragtegy of survival
Forming assoc. bet. Neutral stimulus and food (desire) easy to understand every time hear NS bell
then expect food
Threat Det. (Fear learning)
Amygdala plays crucial role in determining fear
Amygdala calcified no have amygdala Urbach Wiethe disease
Instinctual fear not enough exposure consciously afraid
No amygdala no fearful response that directs that behavior
Stress system
Amygdala detecting threat in env. HPA sys. And starts sending signals designed to deal with threat
Learn these chemicals that being release in level of these axes
Immediate effects of having HPA system activated once you detect threat
Good Memories of Bad Eventsin Infants
Why baby rats approach noxious sit. Than avoid?
Neonatal rat expose in odor and shot
Transitition in Infant learning are modulated
Glucocorticoids GCs cortisol in animals inject then avoidance behavior
Dopamine blocker back to approach odor
Cortisol acting on dopa receptor that is going to produce fearful learning or avoidance behavior
HPA axis remove adrenals where cortisols is secreted no more cortisols
Chronic Stress Triggers Social Aversion
Stress influence avoidance behavior chronic stress and triggers social aversion specific with how this
works
Cage with aggressive animals RATS scary 5mins exposure is one thing but in next 24 hours sleep with
them there is wall stress system active - activate dopaminergic system 0 long term outcomes months
later expose to novel person after 10 days to thataggression high stress reaction if see novel person
changes your life.
Glucocorticoids and Brain Circuity
2 pathways that GC act on that involve with avoidance behavior that become long term in this
aggression
Act directly to nucleus of cell
Cortisol neuron and affect and work on membranes and act of receptor
Stress receptors specialized for GCs
When genetically removed stress receptors on membrance and took out MGR membrane gluco.recep.
Rats no longer avoidance behavior in future
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