PSYC62H3 Lecture Notes - Lecture 10: Weight Gain, Hypomania, Mental Disorder
11 Apr 2017
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Dissociative anesthetics: sedative, pain-reliving drugs that produce feelings of disconnectedness from the body and have depressant and stimulant effects: abuse potential with high medical purpose, researchable. Dissociative anesthetics are no longer used as human anesthetics; they have now been replaced. Recreational use (now, primarily: pcps emerged as a recreational drug during the 1960s. Psychiatric research: pcp or ketamine use produces temporary schizophrenic-like state, model for understanding schizophrenia. Pharmacology: pcp administration include intravenous injection, inhalation, insufflation. Elimination half-life is 18 51 hours. Psychopharmacology: pcp increases serotonin and dopamine (monoamine) nts via: Inhibition of the serotonin and dopamine reuptake transporters. Acting as a agonist for serotonin receptors as partial agonist for dopamine receptors: higher concentrations: Pcp antagonizes nicotinic and muscarinic cholinergic receptors; activates opioid kappa receptors: pcp is an antagonist for glutamate nmda receptors. Interferes with long-term potentiation (form of synaptic plasticity important for learning and memory: ability to increase epsp, to depolarize post-synaptic neuron during.
