PSYB65H3 Lecture Notes - Reuptake
Document Summary
Increase decrease decrease increase increase decrease decrease increase mimicker blocker. Inactivation (reuptake/degradation) decrease increase: monoamines (biogenic amines, cetecholamines, dopamine (da, norepinephrine (ne) Synthesis: dopa da ne: serotonin (5ht) Synthesis: choline acetyl coa acl. Schizophrenia: overactivation of dopaminergic system (cid:173) too many da receptors decrease receptor activation by taking receptor blockers. Parkinson"s disease: underactivation of dopaminergic system (cid:173) too many neurons that produce da died increase synthesis by giving patients dopa dopamine. Epilepsy: repetitive firing/discharge of a hyper-excitable collection (aggregate) of neurons (start doing the same thing at the same time) (cid:173) causes: If age<20, probably something happened during development, eg. trauma , hypoxia (lack of oxygen), congenital defects, infections. If age>35 usually some brain trauma, eg. tumours, strokes, drug abuse (esp. alcohol), infections (damage scar tissue irritates neurons causing them to fire) Epilepsy makes itself progressively worse (cid:173) grand mall seizure. What most people think of when they think about epilepsy.
