PSYC23H3 Lecture Notes - Lecture 3: Glucocorticoid Receptor, Glucocorticoid, Enzyme Inhibitor
Document Summary
Psyc23 lecture 3: social hierarchies and ses: mi(cid:272)hael mea(cid:374)e(cid:455)"s resear(cid:272)h (cid:449)ith rat pups, variation in nurturing experience that rat moms provide, just like human mothers, variation in nurturing experience leads to behavioral and physiological/endocrine differences in pups. Nr3c1 is being down- regulated: high-nurturing lots of expression of gr receptor, able to turn off stress response system, recover faster, show less anxiety, become high- nurturing parent, c: gr receptors are in the hippocampus. Clara rebello: cortisol gets back into the brain and targets these receptors in the hippocampus and other regions of the brain, then hippocampus acts to inhibit activation of hypothalamus less negative feedback. Infants of different animal species exposed to adversity/neglect/abuse: show increased defensive responses. Less fearful in new environments: more glucocorticoid receptors in hippocampus, better regulation of glucocorticoids (cortisol, enhanced gaba inhibition in amygdala. 3x higher than that of men in the highest grade.
