ABS205H1 Lecture Notes - Lecture 8: Metastasis, Angiogenesis
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Bipotent stem cell mutation = basal-like (least chance of survival) all the way to differentiated epithelial cells or myoepithelial cells mutations = luminal a or b (most chance of survival). There is also a preference for each subtype towards particular metastases. Luminal b accumulates in bone significantly more than. Is rate-limiting step as secondary site is foreign to tumor cell: linear progression model: prim. Tumor prolif of cell a cell a disseminates to form prim. Metastasis cell b arises to form sec. This model describes that dissemination only occurs from fully. Malignant cancer cell heterogenous sub pop and have. Arises late in development of primary tumor: better hypothesis: parallel progression model: eg dtcs harbor fewer chromosomal aberrations compared to primary tumor suggesting that tumor cells are getting out early from prim. This would essentially mimic the parallel progression model where early-disseminated cells do not have to accumulate.
