ANA301H1 Lecture Notes - Lecture 1: Methotrexate, Fgf10, Hypoblast
Document Summary
Primary oocyte m1 ovulation secondary oocyte m2 fertilization oocyte. Spermatogonia m1/m2 spermatids spermatogenesis spermatozoa (10 wks) Tur(cid:374)er"s s(cid:455)(cid:374)dro(cid:373)e (cid:894)f(cid:895) - (cid:373)issi(cid:374)g father"s se(cid:454) (cid:272)hro(cid:373)oso(cid:373)e (cid:894)xo(cid:895) Klei(cid:374)felter"s s(cid:455)(cid:374)dro(cid:373)e (cid:894)(cid:373)(cid:895) extra x chromosome (xxy) Secondary oocyte e(cid:374)ter mii (cid:894)do (cid:374)ot (cid:272)o(cid:373)plete u(cid:374)til fertili)ation(cid:895) Rupturing (follicle) weakened ovarian tissue (ischemia stigma) further weakening by proteolytic enzymes release by follicular cells. Omi (oocyte maturation inhibitor) follicular cells manufacture keeps oocyte in suspended phase (do not complete mi) Corona radiata follicular cells covering secondary oocyte (loosely associated, increase size for sperm target) Sperm (zona binding sites) zp3 glycoprotein (zp) trigger acrosome reaction (acrosome membrane fuse w/ sperm membrane and release contents (enzymes): whipping motion of sperm tail + release hyaluronidase and acrosin facilitate zona. Ligands (sperm membrane) bind w/ receptors on secondary oocyte: receptor (integrin family oocyte membrane) + fertilin (disintegrin domain, facilitate attachment, fusion peptide, promote fusion: sperm + oocyte membrane)
