ANT208H1 Lecture Notes - Lecture 8: Dog Bite, Body Fluid, Glucose-6-Phosphate Dehydrogenase Deficiency
Document Summary
Not all result in pathological change (more common after 60, especially 80s) Other forms of dementia: primal temporal lobe dementia, vascular dementia, form tied to prion disease. Dementia: cognitive changes (motor control, personality change, coordination), memory loss. Apoliprotein e: factor influencing frequency of plaque formation; higher plaque formation with apoliprotein e. Ties to inflammatory response and autoimmune conditions (diabetes) Amyloid plaques: found in brain of those without alzheimer"s (correlation, not causation) May be brain"s immune response to pathogens. May be formed to isolate pathogens and encapsulate and deactivate them. Repair framework = not as good with aging or unhealthy brain. Heightened risk at developing dementia with diabetes, cvd. Higher glucose level (breaking down sugars in the brain doesn"t seem to work as well) -> inflammatory response -> higher rates of amyloid plaques. Cessation of menstruation for at least a year.
