Class Notes (906,457)
CA (538,611)
UTSG (45,723)
BIO (2,271)
BIO120H1 (1,175)
Lecture

Notes taken during lecture

2 Pages
68 Views

Department
Biology
Course Code
BIO120H1
Professor
Jean Jiang Nash

This preview shows half of the first page. Sign up to view the full 2 pages of the document.
MAP kinase cascade
Ex. 2 signalling pathways in yeast
Yeast DO mate alpha and beta mating types
Glycerol so cell doesnt desiccate
Same MAP kinase
oWhy doesnt activate wrong pathway?
Because of scaffold proteins, which recruit subset of MAP kinase
Output of each set of proteins can be different so the two
pathways, at the same part, may have different proteins
oLeaves scaffold protein and translocates to nucleus
oCassette idea
Possible to activate one cassette independent of another
JAK/STAT enzyme associated receptor through protein protein interactions
Janus associated kinase
E.g. Jak1, Jak2, Jak3
oEach with different substrate specificity
Transphosphorylation activate
Receptor phosphorylation for docking, for phosphorylation of stat, STATs
dimerize
Binds to DNA turning on or off gene
oSTAT is a transcription factor
EXAMPLE: erythropoietin differentiation red blood cell
Its a cytokine
Erythropoiesis generation of red blood cells
Target genes one of which is haemoglobin
EPO receptor important
oWild type mouse liver is red, where red blood cell production
oKnock out EPO receptor homozygous mutant mouse will grow, without
red blood cells, runs out of oxygen and dies
TGF-beta signalling in animals
Transforming growth factor
oNormal tissue type want to transform it into cancer cell us TGF
oFunctioning as a tetramers***
oEach found as homodimers
oActivated complex = tetramer
oUnidirectional phosphorylation event after tetramerization
oType 2 receptor phosphorylates Type 1 receptor
Dimer that binds is either Smad 2/3 or Smad4 dimer
Dont need to know example of target gene
Turning off a pathway
oDifferent ways
oKnow
www.notesolution.com

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
Description
MAP kinase cascade Ex. 2 signalling pathways in yeast Yeast DO mate alpha and beta mating types Glycerol so cell doesnt desiccate Same MAP kinase o Why doesnt activate wrong pathway? Because of scaffold proteins, which recruit subset of MAP kinase Output of each set of proteins can be different so the two pathways, at the same part, may have different proteins o Leaves scaffold protein and translocates to nucleus o Cassette idea Possible to activate one cassette independent of another JAKSTAT enzyme associated receptor through protein protein interactions Janus associated kinase E.g. Jak1, Jak2, Jak3 o Each with different substrate specificity Transphosphorylation activate Receptor phosphorylation for docking, for phosphorylation of stat, STATs dimerize Binds to DNA turning on or off gene o STAT is a transcription factor EXAMPL
More Less
Unlock Document


Only half of the first page are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit