BIO130H1 Lecture Notes - Lecture 5: Troponin C, Rhodopsin, Peptide

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20 Jan 2017
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BIO130H1 Full Course Notes
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Only one n and one c terminal - rhodopsin is made of one polypeptide, so its tertiary structure is the same as its quaternary structure. It is a polypeptide and a protein at the same time. The domains are often specialized for different functions. Important in the evolution of proteins (1 polypeptide chain may have multiple domains) 1 structural region = 1 domain; 1 polypeptide chain, all covalent bonds. Troponin c has two domains with separate functions. Mammalian phospholipase c has 4 domains, each separate. 4 subunits (2x alpha, 2x beta) forming 1 protein together. Each has its own carbon and nitrogen terminals. Sickle cell anemia is caused by a mutation in the beta subunit. A related molecule, myoglobin, has only one subunit of heme. Made of many proteins, each formed by 1 polypeptide. The definition is not by function: both hemoglobin and this has one united function. Flexible definition: depends case-by-case by who discovered it.

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