BIO130H1 Lecture Notes - Lecture 2: Transcriptome, Interactome, Metabolome
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BIO130H1 Full Course Notes
Verified Note
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Document Summary
Lines of evidence to support endosymbiont theory (eukaryote evolved from pro) Mitochondria and chloroplasts still have remnants of their own genome (genome is circular and looks prokaryotic) Mitochondria and chloroplasts have also kept their own protein & dna synthesis components, some transport machinery. Possible one originated from ancestral aerobic prokaryote itself, and the other from the host which consumed the prokaryote. Central dogma (information flow in the cell. Dna -> transcribed -> rna -> translated -> protein. Dna provides info for mrna, trna, and rrna. Mrna is translated to make proteins trna transports aa"s for protein synthesis rrna is part of the ribosome (also structural and catalytic work) All together make up genome, rna is transcriptome, protein is proteome. Metabolome can impact information dna and rna provide (pyruvate, hormones) Dna, rna, and proteins are linear chains of info with definite polarity. Info in nucleic acid sequence is translated into aa sequence via genetic code.
