BIO130H1 Lecture Notes - Lecture 14: Beta Barrel, Glycosylphosphatidylinositol, Crystallography
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BIO130H1 Full Course Notes
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Document Summary
Blue/purple/orange: polar head group: orange: glycerol, purple: phosphate, blue: vary, hydrocarbon. Green: hydrophobic tails e. g. phosphatidylcholine hydrocarbons tails: vary in length, typically 14-24 carbons, can be saturated or unsaturated saturated: single bond unsaturated: cis double bond - kink not flexible. Changes fluidity of membrane and how lipids can pack together. Cholesterol only has one hydrocarbon tail, hydrocarbon tail can be flexible. There can be up to a 1:1 ratio of cholesterol and phospholipids: decreases mobility of phospholipid tails. When in membrane because rigid steroid ring structure interacts with tails. & provide extra rigidity to tails plasma membrane less permeable to polar molecules. Rigid steroid ring structure between head and tail - stiffer. Phospholipids rapidly: diffuse laterally (move side to side) within each leaflet can rotate, wobble. Phospholipids rarely: rarely move from one leaflet to other (flip-flop or transverse diffusion) indicated by the red line.
