BIO130H1 Lecture Notes - Lecture 22: Tight Junction, Adherens Junction, Claudin

• School: UTSG
• Department: Biology
• Course: BIO130H1
• Professor: All

Document Summary

These are for polarised epithelial cells (ends are different) Dyes, etc can"t get passed these tight junctions. Interact with extracellular domains of proteins in neighbouring cell. If other cell is missing, tight junction fails to seal. Anchoring junctions are necessary for creation of tight junctions. Tight junction can provide some mechanical strength for the cell. Desmosomes (only anchors a specific spot), and hemidesmosomes (like half a desmosome) Actin is tethered to cadherin by anchor proteins. One type of cadherin in one cell will bind to the same one to the other cell. Has to be the same, will not even bind with similar ones. Interactions of cells with others is not just structural. Classical sorting done in 1995 - you mix mesoderm and ectoderm all together. Cadherins form homotypic junctions where the same protein will bind with same one. Specific cadherin family members are the adhesion proteins: desmoglein and desmocollin.