BIO130H1 Lecture Notes - Lecture 2: Polyamine, Ribosomal Rna, Zygosity
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BIO130H1 Full Course Notes
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Document Summary
Week 2 introduction to nucleic acid and protein. Attraction can be shield by water: hydrogen bond. Not strong on angle: vander waals attractions. Can become strong when there are stack of it: hydrophobic force. Nucleic acid chains: dna is synthesized from deoxyribonucleside triphosphates (dntps, rna is synthesized from ribonucleoside triphosphates (ntps, nucleotides are linked by phosphodiester bonds. Three forces that keep dna together: hydrogen bond (between nitrogenous base, van der waals attraction (layers of the dna, force is strong together) Hydrophobic interaction (hydrophilic sugar- phosphate backbone, hydrophobic base) Two chain of double helix are antiparallel (5"3"-3"5") 5" end consist phosphate group, 3" end consist h or oh (rna) Sugar phosphate group facing outside, phosphate group giving it a negative charge (hydrophilic) Pyrimidine (t (u), c) always pare with purine (g, a) (a-t)(g-c) Major groove is the better protein binding sites with larger opening information.
