Drug favours malarial variants to are resistance to the drug. When we use these drugs we are doing a selection experiment on the pathogen. Prevent larva pupilation target the adult stage if you keep spraying mosquitoes, eventually they will evolve resistance. Eventually pesticide will favour an insecticide resistant mosquito they are unaffected but everyone else is not, and unaffected group replicates while others do not. Antibiotics are favouring bacterial genotypes that are not susceptible. Tuberculosis: recently in india, resistant strains of tuberculosis have developed, has a lot to do with better housing and sanitation. Sometimes bacteria sometimes do not reproduce completely asexually. Donor give a replicate of plasmid to individual without a plasmid resistance. Resistance is transferred from good bacteria to bad bacteria accidentally. Hiv the evolution of resistance through new mutation. Hiv is a virus viruses cannot replicate, they take over the machinery of their host. Host dna"s replication machinery starts to produce mrna.