BIO230H1 Lecture Notes - Lecture 8: Stoma, Methylation, Lysine
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BIO230H1 Full Course Notes
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Bio230 lecture 8 - regulation of the proteome (oct. 3) Have looked at regulation of translation, transcription. But even after protein is produced, need more regulation. Sometimes proteins don"t fold properly (become aberrant = not properly functional) Cell needs to detect/remove proteins so they don"t contribute to toxic diseases. Now we are at the protein level. Still a lot of regulation that has to go on. Proteins crucial because carry out most of function of genome. Protein undergo number of steps to become functional: [1] proteins must fold properly + adopt 3d structure (alpha helices and beta strands, then those structures form 3d structures) [2] proteins are covalently modified with chemical groups (sugars/phosphate) [3] proteins interact with other proteins + small molecules (cofactors) Cofactors might be important for activation of proteins. Hydrophobic amino acids (aa) tend to be buried in the interior core. Hydrophobic aa part of aa sequence fold so that they"re in the middle.
