BIO230H1 Lecture Notes - Lecture 12: Myc, 23S Ribosomal Rna, Clathrin

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8 Feb 2016
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BIO230FINALEXAM2011ANSWERKEY
1D2A3C4B5A 6B 7C 8D9A10B
11C12ABCD13A14B15D 16C 17A 18B19C20B
21A22B23C24D25A 26B 27C 28D29D30C
31B32B33A34C35A 36D 37A 38D39A40CD
41B42C43C44B45C 46A 47D 48C49B50B
51D52A53D
1. IfachemicalthatinhibitsPI3kinasewereaddedtocells,whichofthefollowingwouldoccur?
a. Specificproteinswoulddissociatefromthecytosolicfaceofcellmembranes.
b. TheconcentrationsofPIP2specieswouldbeaffected.
c. Rabactivitieswouldbeaffected.
d. Alloftheabove.
2. Inacellwithaclathrinmutation,whichofthefollowingwouldmostlikelybeaffected?
a. Endocytosis.
b. Transportofmoleculesfromtheendoplasmicreticulumtothegolgiapparatus.
c. Transportofmoleculesfromthegolgiapparatustotheendoplasmicreticulum.
d. Transportofmoleculesbetweengolgicisternae.
3. Whichofthefollowingstatementsconcerningvesicleregulationisincorrect?
a. Inositolphospholipidsarephosphorylated.
b. Rab5GDPisconvertedtoRab5GTPbyRab5GEF.
c. Rab5Aislocalizedonlateendosomes.
d. ThepresenceofRab5GTPandPI(3)Pformsacoincidencedetector.
4. Howmanyofthefollowingcomplexes/proteinsdrawtwolipidbilayersintodirectcontact?
Clathrin
Dynamin
SNAREproteins
RabsmallGTPases
a. 1
b. 2
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c. 3
d. 4
5. Anartificialmembraneboundcontainerisfilledwithpurifiedtubulinsubunits,apurfied
centrosome,purifiedDyneincomplexesandthenecessarysmallmoleculesforproteinactivities.
Overtime,wherewouldtheDyneincomplexesaccumulate?
a. Nearthecentreofthecompartment.
b. Neartheoutermembraneofthecompartment.
c. Onmicrotubulesthroughoutthecompartment.
d. Homogenouslythroughoutthecompartment.
6. Howmanyofthefollowingstatementsaretrue?
Actinsubunitsandtubulinsubunitsarebothasymmetric.
ActinsubunitsandtubulinsubunitsbothbindATP.
Actinsubunitsandtubulinsubunitsarebothmonomeric.
Actinandtubulinfilamentsarebothformedfrommultipleprotofilaments.
a. 1
b. 2
c. 3
d. 4
7. Whichofthefollowingcellsusediffusibleextracellularsignalsastheirprimarymechanismto
positionthemselvesinspace?
a. ReassociatingXenopusgermlayercellsanddevelopingflysensorybristlecells.
b. ReassociatingXenopusgermlayercellsandpathfindingcommissuralneurons.
c. Pathfindingcommissuralneuronsandmigratingimmunecells.
d. Migratingimmunecellsandmigratingneuronalcellbodiesinthecerebralcortex.
8. Whichofthefollowingisleastlikelytobestructurallysupportedbyanactinnetwork?
a. Theadherensjunction.
b. Thegrowthcone.
c. Thecytokineticring.
d. TheGolgiapparatus.
9. Anoccludinmutationin__________cellswilldirectlyaffect__________.
a. intestinalepithelial;glucosetransport.
b. Drosophilaembryonic;movementoftheouterepithelium.
c. Drosophilaembryonic;segmentationoftheouterepithelium.
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d. epithelial;adherensjunctionformation.
10. Howmanyofthefollowingstatementsregardingconnectivetissueareincorrect?
Cellsusetreadmillingactinnetworksandintegrinstomovethroughthetissue.
Thetissueisprimarilysupportedbydirectconnectionsbetweencells.
Thetissueformsourskin.
Connectivetissuecellsincludemusclecells.
a. 1
b. 2
c. 3
d. 4
11. Whichofthefollowingstatementsconcerningcellpolaritycues/landmarksiscorrect?
a. InC.elegans,theareawherethespermenterstheeggistheareathatdevelopsanteriorcues.
b. Landmarksonlyinduceapicalcuessincebasalmembranepropertiesaresimplytheabsenceof
apicalmolecules.
c. Complexesattheadherensjunctionsignalregionsnearbytodevelopapicalcues.
d. Thehighexpressionofadherensjunctionsserveaslandmarksfortumordevelopment.
12. Whichofthefollowingstatementsconcerningseaurchingastrulationiscorrect?
a. Initially,epithelialcellsbreaklooseandcrawlovertheinnerfaceofthewalloftheblastula,
becomingtheendoderm.
b. Threegermlayersarecreated:theendoderm,mesodermandepidermis.
c. Themesodermdevelopsintothemusclesandnervoussystem.
d. Theendodermdevelopsintothegutandlungs.
13. Whattwoprocessesareprimarilyresponsibleforplanttissuemorphogenesis?
a. Celldivisionandcellshapechange.
b. Cellshapechangeandcellsorting.
c. Cellsortingandcellmigration.
d. Cellmigrationandcelldivision.
14. Whichofthefollowingstatementsmakesthebestargumentforacommonevolutionaryoriginfor
animals?
a. Specificgermlayersarepositionedinsideembryosusingthesamemorphogenesismechanisms
indifferentanimals.
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