BIO271H1 Lecture Notes - Lecture 2: Second Messenger System, Information Transfer, Nicotinic Acetylcholine Receptor

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8 Mar 2016
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Triggered by the net graded potential at the axon hillock. Caused by the opening and closing of sodium and potassium channels. If that sum reaches threshold, then an action potential will fire and there will be a signal. It"s not one action potential that moves along the axon action potentials are all or none: it will fire or not, same shape, duration, and size action potentials happen in neurons or muscle cells. Depolarizing graded potential, reaches threshold, opens sodium channel, depolarizing membrane further, leading to the opening or more sodium channels, more depolarization. Open probability: probability that channels will open increases with a greater depolarization. Drives the rapid increase of depolarization: very few ions move to change the membrane potential, single action potential has no measurable effect on ion concentration. Neuron can still fire thousands of action potentials even if the sodium potassium atpase isn"t working because so few ions are needed. Voltage gated sodium channel: activation gate, inactivation gate.

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