BCH210H1 Lecture 8: L8

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Lecture 8: attraction between oppositely charged species (+, ), especially protonated amino and ionized carboxylate groups, arg (+ve, asp ( ve) Hydrogen bonds: stabilizing, attractive interaction between a proton (often part of a polarizable bond such as. Nh, oh or sh) and an electron donating species (often c = o) Important for protein structure such as the alpha helix. C = o bond is the donor of electrons, the n h proton is the acceptor. When that occurs structure water is reduced; entropy increases when water is released. Van der waals interactions: stem largely from favorable (non repulsive) interactions between side chains, based on proximity and packing, it will be packed at, but not closer than the van der waals contact distance. Proteins have different structures to allow this type of interaction. Ridges into grooves : van der waals packing; close contacts occur between protein segments.