BCH210H1 Lecture Notes - Lecture 19: Maud Menten, Amine, Chemical Kinetics
49
BCH210H1 Full Course Notes
Verified Note
49 documents
Document Summary
If enzyme doesn"t have substrate, a chemical reaction will not occur. With strokes or heart attacks for example, a substrate becomes available --> the enzyme phospholipase a2 gets activated by phospholipids that are released. Arachidonic acid is made from this as a result of phospholipid and phospholipase a2. Arachidonic acid is 20:4, an omega-6 polyunsaturated fatty acid. In the presence of oxygen, cox (part of dehydrogenases) will oxygenate arachidonic acid, creating the precursor to eicosanoids, which can have harmful effects as listed below. Stay away from rattlesnakes because their venom is full of phospholipases. The breaking down of membranes accounts for the physiological effects of the pain. Get to the hospital asap to get antivenom which itself has inhibitors of phospholipases. Phosphorylation, for example, on s or t residue (oh residue) --> reversible. Pyruvate dehydrogenase is responsible for making acetyl coa (oxidoreductase) Has its own kinase which uses atp to deactivate it (removal = activation)
