BCH210H1 Lecture Notes - Lecture 15: Peripheral Membrane Protein, Fluid Mosaic Model, Hydrophobicity Scales

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Exclusive focus on proteins that sit within those lipids that we"ve discussed, and how they make cells function. Fluid mosaic model lipids and proteins float freely: modern fence model free fluidity with physical barriers (fences) both underneath and on top that restricts the motion. Three different kinds of proteins, properties of each. Plasma membrane allow transmission of signals via transduction through membrane proteins from the outside to inside the cell. Intrinsic, extrinsic, anchored: outline unique properties of integral proteins, extracellular vs. intracellular vs. transmembrane, describe membrane protein prediction concepts. Membrane protein classes a, b = integral (intrinsic, transmembrane) c, d = peripheral (extrinsic) Integral membrane protein is a protein that goes completely through the bilayer. Intrinsic membrane protein sits on the top or bottom, dipping a little bit into the bilayer sometimes. 1 peripheral membrane proteins: adhere to membranes or integral membrane proteins through noncovalent interactions, operational definition: removable with mild disruption (high salt or small ph change)