BCH210H1 Lecture Notes - Lecture 34: Squalene, Cardiovascular Disease, Acetoacetyl-Coa

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Transporting fats throughout the body, diet vs. genetics . Finish discussion about fat synthesis: we"ve covered majority of metabolic pathways, cholesterol is transported in a lipoprotein complex throughout the body via the bloodstream, ch. 9. 1, 4, 5: end of chapter problems ch. 9: 1, 2, review questions posted on blackboard, socrative room # 317683. Large hydrophobic rings: hydroxyl group give it a polar characteristic, all carbons come from acetyl coa. Cholesterol synthesis in the liver: cholesterol is crucial for membrane biochemistry and as a precursor for hormones, bile salts, and vitamin d3 production. Structure that"s used to make other molecules in cholesterol metabolism to make hormones, bile salts (in digestion for solubilization of other fats), and vitamin d3. 3 acetyl coas come together to form a mevalonate (6cs) in the cytoplasm. The one enzyme that"s regulated is hmg-coa reductase, which makes mevalonate: we can turn off cholesterol synthesis through phosphorylation, which inactivates hmg-coa reductase.