BCH210H1 Lecture Notes - Aliphatic Compound, Carboxypeptidase A, Isoleucine

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11 Sep 2013
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BCH210H1 Full Course Notes
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BCH210H1 Full Course Notes
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Chemicals of life: nucleic acids, amino acids, carbohydrates, lipids, steroids, na+, k+, ca+2, cl-, po4 -2. Four nucleotides: adenine, guanine, thymine, cytosine (purines= a,g ; pyrimidines= t, c) Hemoglobin = 4 chains of amino acids folded up. Backbone conformation of a folded protein ex: carboxypeptidase a direction and propagation of this chain only goes one way. Amino acids as monomers are in a zwitterionic form (have a positive and a negative side) Zwitterionic form of amino acid the amino acids are in this form during physiological activities, almost always see amino acids this way. Amino acids are structurally asymmetrical (alpha carbon of an amino acid is an asymmetric center) Two forms to arrange (l-isomer, d-isomer non super imposable) All amino acids and proteins have the l configuration d configuration is something that happened after the protein is synthesized not known why. Peptide bond is formed between the carboxyl group with the amino group end up eliminating water.

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