BCH210H1 Lecture Notes - Lecture 30: Carboxy-Lyases, Thiolase, Hydrolysis

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Ci: hexose sugars (high affinity for 6cs, not just glucose) Pf: amp (breakdown of atp = need more) Nf: atp (too much atp = stops pk), acetyl-coa, alanine. Phos: phosphorylation = inactive (spec. to liver, low plasma [glucose]), dephosphorylation = active (high plasma [glucose], good for atp), done by pka. Pf: acetyl-coa (build-up = needs oaa to enter tca) Nf: adp (cid:894)(cid:271)(cid:396)eakdow(cid:374) of atp = do(cid:374)"t wa(cid:374)t to make glucose) Pf: activated by amp and adp (hyperbolic curve) Nf: atp (too much atp = not worth, sigmoidal), citrate, h+ Amp and atp compete for allosteric site (high amp = hyperbolic, high atp = sigmoidal) Nf: f-2,6-bp (this stimulates pfk-1, so want to stop breakdown) of f-1,6-bp, amp + adp (sign of glycolysis) Sa: presence of f-6p (sign of pfk-1 not acting fast enough) Depleting products (dhap and gap) drives fwd rxn (b/c +ve. Nf: adp (cid:894)(cid:271)(cid:396)eakdow(cid:374) of atp = do(cid:374)"t wa(cid:374)t to (cid:373)ake glu(cid:272)ose(cid:895)