BIO120H1 Lecture Notes - Lecture 7: Euchromatin, Gene Expression, Chromatin
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BIO120H1 Full Course Notes
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Gene expression actually just starts with chromatin & actually ends ultimately with the proteins that interact together. Need to consider the multitude of different factors that function to regulate transcription itself & modify chromatin structure. Movie: modifications can occur at different steps: capping enzyme, putting 7-methyl-guanine one, we"ve got splicing that can occurs (introns being removed), poly-adenylation occurs & eventually have migration out of the nucleus out into the cytoplasm. & now the events involved in translation & the control thereof. Insulators & barrier sequences are important for defining zones of gene regulation, making sure that where gene expression occurs is going to be euchromatin & where gene repression occurs is heterochromatin. The 2 zones are effectively, to a good extent, isolated from each other. Insulators function to make sure that genes function as discrete units, that is, they block the activity of dna motifs known as enhancers this is where transcriptional activator proteins would bind to these enhancer sites.
