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BIO130H1 (434)
Lecture 6

Lecture 6 Part 1

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Department
Biology
Course
BIO130H1
Professor
Jane Mitchell
Semester
Fall

Description
Lecture 6 Part IFeb 912DNA Replication IIIDNA proofreading 135 proofreading exonuclease 2Stranddirected mismatch repairaMutS and MutL proteinsbBase excision repaircNucleotide excision repairProofreading exonucleaseImproper nucleotide pairing prevents further elongationCleaves improperly matched nucleotide Occurs at end of synthesized strand Found on the e exonucleolytic site of DNA polymerasePolymerase Polymerizing P site and e site occur almost simultaneously Reason of 53 synthesis Allows for efficient error correctionchain growthDNA polymerase requires energy to catalyze synthesis Only 53 can provide co
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