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Lecture 9

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Department
Biology
Course
BIO130H1
Professor
Jane Mitchell
Semester
Winter

Description
Ppt16 RNA polymerase II C-terminal tail In RNAP II only the carboxy terminal domain of the largest subunit has a stretch of 7 amino acids that is repeated multiple times 1)Repeat = Tyr-Ser-Pro-Thr-Ser-Pro-Ser 2)Yeast enzyme has 26 repeats along CTD 3)Human enzyme has 52 repeats CTD This region is essential for viability Ppt18 How is RNA polymerase II activated? Phosphorylation ( the phospres +CTD) What is phosphorylated? Adding phosphate groups on S (Ser) at CTD 3) How many proteins are involved in initiating located on the CTD eukaryotic transcription? >100 subunits Ppt20 RNA Processing *5’ pre-mRNA capping (remove phosphate, add GMP, add mthl group to G base) -protects RNA from exonucleases -last step is in some caps *5’ to 5’ link of triphosphate bridge. *intron get removed, exon lik together =mRNA Pre-mRNA s
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