CSB202H1 Lecture Notes - M1 Protein, Epitope, Antigen
3 Jun 2013
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Document Summary
Limited by the fact that must do tests in animal models always imperfect. Cannot test vaccines on humans without testing in mice or other animal models so if the latter is unsuccessful, a potentially successful human vaccine may never reach the population. Childhood vaccine some vaccines may have no effect in adults but protective in children. Not a good antibody response it has elicited a memory response boost this later on . Getting vaccines for younger children one dose focus on adjuvant. Maternal antibody can inactivate or suppress response to vaccine problem! Immunize mother if half-life is similar, more antibody given to child at time of birth, protection for a longer time . Amount of antibody decreased in immunized mothers at four weeks, similar levels of antibody regardless of whether mother was immunized or not. Pup making the antibodies in the non-immunizd mother whereas in immunized mothers, at 4 weeks, mostly maternal anitobides.
