CSB325H1 Lecture Notes - Lecture 6: Angiotensin, Renin, Epithelium
11 Apr 2017
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Page 1: diuresis is most important across organisms. Page 2: need to have a constant ratio, so changing volume changes solutes, permeability. Depending on type of phospholipids, may or may not interact. Cholesterol in the membrane will act to separate phospholipids and make the membrane more permeable, more liquid. E. g. blood loss, renal failure: decreased es volume: A. 1: lots of regulation to make sure this doesn"t happen. Can die from drinking too much water without eliminating. Ace chops off another 2 aas to produce angiotensin-ii, which is the most effective and potent of the two forms. Page 7: renin removes protein tail: leu-val-tyr-ser-protein, ace removes last 2 aa: his-leu, don"t memorize these sequences, angiotensin-i is a decapeptide, angiotensin-ii is an octapeptide. Page 8: angiotensin-ii makes you thirsty, talking about medulla before, now talking about the cortex, different pathway is aldosterone, a mineralocorticoid. But going to use this as the model for vertebrates (fish have something)
