Lecture 18

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University of Toronto St. George
Cell and Systems Biology
Mounir Abou Haidar

081107Lecture 18details of Prion movie shown from 12pm on this day are omittedLecture notes begin3 min 40 sec into the recordingToday I am going to cover PicornavirusesI will go over the polioviruses first then I will go back to Rhinoviruses and Hepatitis A virusthey are all PicornavirusesPICORNAVIRIDAEPg 109Polio viruses are part of the PICORNAVIRIDAE mammalian viruseswhich includes Enteroviruses Polio Coxsackie virus and Enteric cytopathogenic human orphan ECHOECHO is named as such because it is enteric goes to the gutsgives you diarrehea cytopathogenicdestroys some of the lining of the intestine like most of these viruses human orphanyou cannot pin the disease directly to the virus because there are a lot of Enteroviruses in the guts and they all look alike icosahedralThen we seeRhinovirusesHepatoviruses Hepetitis ACardioviruses Encephalymyocarditis virus EMCit will hit the brain and theheartAphtoviruses Foot and Mouth Diseasemostly an animal virus found in the UK know a bit about it but this is an animal virusIt is not pathogenic for humansit will only cause a mild rash on the hands and arms Foot and Mouth disease is a serious problem in some countries and great measures have been taken to prevent its entry into Canada ie wiping feet on an acidified carpet whenreturning from a country with this diseaseacid will destroy the viruspg 110The virus has a T1 60 subunitsThey are SS RNA and they have a cellular receptor on chromosome 19the ICAM1 ICAMintracellular adhesion moleculeThey have a polyA tail are cap independent and translation occurs via IRES IRESinternal ribosome entry sitePicornaviruses do not produce subgenomics as they have one ORFmeaning they have one AUG and one termination codon and they produce a single polyproteinFollowing translation the polyprotein must be processed into functional proteins supl to pg 11656 of 21you dont have to memorize all of the receptors to PicornavirusesPolio viruses infect cells via the CD155 receptor Coxsackie A virus infect cells via the ICAM1 receptorECHO infect cells via the VLA2 most Picornaviruses infect cells through adhesion molecules molecule that hold cells togetherThese are RNA viruses so replication is 100 cytoplasmicthat is the viruses do not go to the nucleus
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