CSB429 Lecture 3.docx

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Cell and Systems Biology
Dorothea Godt

CSB429 Lecture 3 2/1/2013 3:53:00 PM Germ plasm in Drosophila - contains polar granules = large complex cels of protein and RNAs Molecules to start making granules/ the starting protein is OSKAR (in flies – not conserved out of insects) Oskar  Vasa  Tudor What are these granules? This is present at the posterior Where are the RNAs coming from? end Maternal Factors: all factors put into the egg during oogenesis. Many are proteins, the rest = RNAs ZYGOTE - Maternal mRNAs specifically localized to germ plam - 3’ UTR of these mRNAs imp for the localization - Experiment: KO the pathway to see Maternal mRNAs 30% of the RNA in germ cells comes from the germ plasm. BLASTODERM: large portion of the maternal mRNA are degraded w/ the exception of the PGCs  they preserve the maternal components! Somatic cells mRNAs get degraded Primordial germ cells (170 transcripts) Two important processes: - Localization of RNAs - Degradation of RNAs in somatic but not the PGCs Early embryo: - no transcription b/c it has things from oogenesis ] - the mitosis cycle only consists of M and S phase (G1 and G2 are el
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