CHM136H1 Lecture Notes - Lecture 11: Steric Effects, Van Der Waals Strain, Cyclohexane Conformation
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CHM136H1 Full Course Notes
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Document Summary
Substituted cyclohexane rings occur widely in nature, they are free of angle strain and torsional strain. The chair conformation has two kinds of positions for ring substituents: Axial positions and equatorial positions. interconvert resulting in exchange of axial and equatorial positions by a ring flip. Cyclohexane is not a static molecule, constantly undergoing ring flips under room temperature. Two conformations of any monosubstituted cyclohexane arent equally stable. Cyclohexane ring rapidly flips between chair conformations at room temperature. *equatorial conformer of methyl cyclohexane more stable than axial. 1,3-dixial interactions: difference between axial and equatorial conformers due to steric strain caused by. 1,3-dixial interactions: the h atoms of ch3 group on c1 are too close to axial hydrogens 3 carbons away from c3 and c5 and result in 7. 6kjmol of steric strain. The steric effects of both substituents must be taken into account in both conformations.
