CSB327H1 Lecture Notes - Lecture 2: Type I Collagen, Hyaline Cartilage, Fibril
Document Summary
Tissue specific 3d array of type i collagen. *3d orientation depends on the direction of applied forces. 3 left-handed alpha chains (helices) super-coiled to form a right handed supercoil. Sequence of the molecule at the c-terminal dictates which chains assemble (only assemble with their respective types) and is where assembly begins. Made of repeating subunits (collagen molecules, d banding morphology of fibrils) Oriented in the direction of force (this is different in different tissues) Trimer of 3 alpha chains (left-handed polyproline helices) assembled into a right-handed helix (staggered by one amino acid) (gly-x-y) repeat (x & y are usually pro,oh-pro residues) Helical trimer of 3 alpha chains is referred to as a collagenous domain . Provides tensile strength and gives shape to our organs. No such thing as a pure type i collagen. There are always other"s that help nucleate (type v), organize assembly (fibronection and integrins), and organize fibril pattern/orientation (proteoglycans, glycoproteins)
