CSB328H1 Lecture Notes - Lecture 11: Dermis, Neurotrophin-3, Claudin
20 Oct 2016
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Lecture 11 (october 19, 2016): what causes differential gene. All the cells in an organism have the same set of genes, but they can have different gene products and thus different cell fates. Two things that control gene activity in the nucleus: cytoplasmic factors. Nucleus is competent to activate neural specific genes: leads to neuronal cell types. If we put the neuronal progenitor cell in the cytoplasm of an oocyte, the nucleus is reprogrammed is competent to activate early developmental gene: can initiate development of a whole organism. Yellow cytoplasm holds cytoplasmic factor macho-1 which is a muscle determining factor. The other cells will not develop muscle because they lack macho-1. Important in regulating gene activity: cell-cell signalling. At a time when the dorsal mesoderm has involuted, it is the organizer that produces chordin, noggin, and follistatin. Those secretions block bmp signalling in the overlying ectoderm and prevent the epidermal fate.
