CSB328H1 Lecture Notes - Lecture 23: Positive Feedback, Limb Bud, Fgf10
8 Dec 2016
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Document Summary
Fgf10 induces the apical ectodermal ridge, leading to the growth of the limb bud. Limb bud formation begins: half a day later. Location of the cartilage of the first bone is set (the humerus) The first element that begins to differentiate is the most proximal structure: day 13. A, z, and s are all formed: after day 14. Remove surgically the aer from the rest of the limb bud, which still consists of limb mesenchyme. Removed at three stages: very early on in development (3 days) Results: only the most proximal structures grow: after 3 and a half days. Results: s and z form: after 4 days. Results: s, z, and a as well as distal elements form. Limb bud stops growing when aer is removed. Aer is important for the increase of limb mesenchyme. Aer makes and secretes fgf8: there is no other place in the limb bud where fgf8 is expressed.
